Insights from

Nobel Laureates, for scientists everywhere

Michael Brown

Michael Brown

Michael S. Brown received a B.A. degree in Chemistry in 1962 and an M.D. degree in 1966 from the University of Pennsylvania. He was an intern and resident at the Massachusetts General Hospital, and a postdoctoral fellow with Dr Earl Stadtman at the National Institutes of Health. In 1971, he moved to the University of Texas Southwestern Medical Center in Dallas, where he rose through the ranks to become a professor in 1976.

He is currently Paul J. Thomas Professor of Molecular Genetics and Director of the Jonsson Center for Molecular Genetics at UT Southwestern. Dr Brown and his long-time colleague, Dr Joseph L. Goldstein, together discovered the low-density lipoprotein (LDL) receptor, which controls the level of cholesterol in blood and in cells. They showed that mutations in this receptor cause familial hypercholesterolemia, a disorder that leads to premature heart attacks in one out of every 500 people in most populations.

They have received many awards for this work, including the US National Medal of Science and the 1985 Nobel Prize for Medicine or Physiology.

What do you look for in job applications?
Joseph Goldstein and Michael Brown

What do you look for in job applications?

Do results ever surprise you?
Michael Brown

Do results ever surprise you?

How do you choose the right lab to work in?
Joseph Goldstein and Michael Brown

How do you choose the right lab to work in?

What did your early mentors teach you?
Joseph Goldstein and Michael Brown

What did your early mentors teach you?

Why is a partnership so rewarding?
Joseph Goldstein and Michael Brown

Why is a partnership so rewarding?

Do scientists need to work long hours?
Joseph Goldstein and Michael Brown

Do scientists need to work long hours?

How certain should you be before you publicise a new discovery?
Joseph Goldstein and Michael Brown

How certain should you be before you publicise a new discovery?

What does it take to be a successful scientist?
Michael Brown

What does it take to be a successful scientist?

How important is interaction between scientists and clinicians?
Michael Brown

How important is interaction between scientists and clinicians?

Why did you decide to stop practising as a physician?
Michael Brown

Why did you decide to stop practising as a physician?

Was it a sacrifice to stop being a clinician?
Michael Brown

Was it a sacrifice to stop being a clinician?

How has the environment for physician-scientists changed?
Michael Brown

How has the environment for physician-scientists changed?

How have you maintained your partnership with Joe Goldstein for four decades?  Part 2.
Michael Brown

How have you maintained your partnership with Joe Goldstein for four decades? Part 2.

How have you maintained your partnership with Joe Goldstein for four decades?  Part 1.
Michael Brown

How have you maintained your partnership with Joe Goldstein for four decades? Part 1.

How did your research collaboration with Joe Goldstein start?
Michael Brown

How did your research collaboration with Joe Goldstein start?